PROTAC targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques (via transgene expression or CRISPR-mediated locus-specific knock-in). Application of dTAG-13 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. dTAG is generalizable to a range of fusion proteins; useful as an alternative to genetic methods for target validation.
Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.
dTAG-13 is a degrader targeting mutant FKBP12F36V fusion proteins. Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-13 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins
in vitro
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-124612 |
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| Réf. fabricant | 18796009 |
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| Nom chimique ou matériau | 1-[(2 S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2 S)-2-piperidinecarboxylate (1 R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester |
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| CAS | 2064175-41-1 |
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| Quantité | 5 mg |
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| Cible | TAG Degradation Platforms |
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| Formule moléculaire | C<sub>57</sub>H<sub>68</sub>N<sub>4</sub>O<sub>15</sub> |
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| Poids de la formule | 1049.18 |
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| Pureté | 98% |
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