Lalistat 1 is a potent and selective lysosomal acid lipase (LAL) inhibitor (IC50 = 68 nM). Exhibits no significant activity against pancreatic lipase or lipoprotein lipase at 10 μM concentration. Blocks LAL-mediated lipid hydrolysis of acetylated LDL and reduces efflux of cholesterol from lipid-loaded cells resulting in increased cellular cholesterol ester levels.
- Nom chimique ou matériau
- 4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate
- CAS
- 501104-16-1
- Plage de pourcentage du dosage
- >98%
- Quantité
- 50 mg
- Formule moléculaire
- C12H18N4O3S
- Poids de la formule
- Observed MW: 298.36
