Histone deacetylase (HDAC) inhibitor (IC50 = 7.5 to 16 nM). At low concentrations reduces release of pro-inflammatory cytokines, including TNFα, INFγ, IL-1α and IL-1β, from LPS stimulated PBMCs in vitro. Exhibits anti-inflammatory effects in vivo. Improves functional recovery and attenuates tissue damage in a mouse model of traumatic brain injury.
- Nom chimique ou matériau
- [6-[(Diethylamino)methyl]-2-naphthalenyl]methyl-N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate hydrochloride
- CAS
- 199657-29-9
- Plage de pourcentage du dosage
- >98%
- Formule moléculaire
- C24H27N3O4.HCl
- Poids de la formule
- Observed MW: 457.95
