Givinostat hydrochloride

Réf. : 18759466
141.47€ - 518.35€€

Histone deacetylase inhibitor

Nom chimique ou matériau
[6-[(Diethylamino)methyl]-2-naphthalenyl]methyl-N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate hydrochloride
CAS
199657-29-9
Plage de pourcentage du dosage
>98%
Quantité
5 mg
Formule moléculaire
C24H27N3O4.HCl
Marque
Tocris

Givinostat hydrochloride is a histone deacetylase (HDAC) inhibitor (IC50 = 7.5 to 16 nM). At low concentrations reduces release of pro-inflammatory cytokines, including TNFα, INFγ, IL-1α and IL-1β, from LPS stimulated PBMCs in vitro. Exhibits anti-inflammatory effects in vivo. Improves functional recovery and attenuates tissue damage in a mouse model of traumatic brain injury.
Nom chimique ou matériau
[6-[(Diethylamino)methyl]-2-naphthalenyl]methyl-N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate hydrochloride
CAS
199657-29-9
Plage de pourcentage du dosage
>98%
Quantité
5 mg
Formule moléculaire
C24H27N3O4.HCl
Poids de la formule
Observed MW: 457.95