Potent pan-Akt and PKA inhibitor
AT 7867 is a potent pan-Akt (protein kinase B) and protein kinase A (PKA) inhibitor (IC50 values are 32, 17, 47 and 20 nM for Akt1, Akt2, Akt3 and PKA, respectively). Also inhibits p70-S6 kinase (p70S6K, IC50 = 85 nM). Inhibits Akt signaling and proliferation of multiple human cancer cell lines, including breast, prostate and colon. Promotes proliferation of iPSC-derived PDX1+ pancreatic progenitor cells (PPCs).
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124746 |
| Réf. fabricant | 18796776 |
| Nom chimique ou matériau | 4-(4-Chlorophenyl)-4-[4-(1 H-pyrazol-4-yl)phenyl]piperidine hydrochloride |
| Quantité | 50 mg |
| Cible | Akt (Protein Kinase B) Inhibitors |
| Formule moléculaire | C<sub>20</sub>H<sub>20</sub>ClN<sub>3</sub>.HCl |
| Pureté | 0.98 |
