Potent and selective vasopressin V1B antagonist
SSR 149415 is a potent and selective vasopressin V1B antagonist (Ki values are 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Displays >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 α-pancreatic cells
in vitro
. Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124796 |
| Réf. fabricant | 18745636 |
| Nom chimique ou matériau | (2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide |
| CAS | 439687-69-1 |
| Plage de pourcentage du dosage | >98% |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>30</sub>H<sub>32</sub>ClN<sub>3</sub>O<sub>8</sub>S |
| Poids de la formule | Observed MW: 630.11 |
