Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs
Thalidomide-4-hydroxyacetate is a derivative of Thalidomide (Cat.No. 0652), commonly used as a precursor to PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.
Thalidomide-4-hydroxyacetate has been recently renamed. The previous name for this product was TC E3 5031.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124805 |
| Réf. fabricant | 18729768 |
| CAS | 1061605-21-7 |
| Synonyme | 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid |
| Quantité | 100 mg |
| Cible | Degrader Building Blocks |
| Formule moléculaire | C<sub>15</sub>H<sub>12</sub>N<sub>2</sub>O<sub>7</sub> |
| Poids de la formule | 332.26 |
| Pureté | 98% |
