High affinity prolyl oligopeptidase inhibitor (Ki = 0.023 nM); anti-angiogenic, neuroprotective and brain penetrant
KYP 2047 is a high affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. It reduces tau aggregation in tau-transfected HEK-293 cells and N2A cells as well as in human iPSC-derived neurons from patients with frontotemporal dementia.
In vivo
, treatment with KYP 2047 of transgenic mice with tauopathy, reduces tau aggregation in the brain and cerebrospinal fluid and slows cognitive decline. Anti-angiogenic and neuroprotective. Brain penetrant.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124811 |
| Réf. fabricant | 18765746 |
| Nom chimique ou matériau | (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile |
| CAS | 796874-99-2 |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>20</sub>H<sub>25</sub>N<sub>3</sub>O<sub>2</sub> |
| Poids de la formule | 339.44 |
| Pureté | 98% |
