"/> Tocris Bioscience™ PF 05175157 | B-LABO France

Tocris Bioscience™ PF 05175157

Réf. : BL-RE-124818Réf. fabricant : 18789228 50 mg
682,49 € HT

Acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor

Nom chimique ou matériau
1,4-Dihydro-1′-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4′-piperidin]-7(6H)-one
CAS
1301214-47-0
Quantité
50 mg
Cible
Additional Lipid Metabolism Compounds
Formule moléculaire
C23H27N5O2
Marque
Tocris Bioscience

PF 05175157 is an potent acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic

de novo

lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-124818
Réf. fabricant18789228
Nom chimique ou matériau1,4-Dihydro-1′-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4′-piperidin]-7(6H)-one
CAS1301214-47-0
Quantité50 mg
CibleAdditional Lipid Metabolism Compounds
Formule moléculaireC<sub>23</sub>H<sub>27</sub>N<sub>5</sub>O<sub>2</sub>
Poids de la formule405.49
Pureté>98%
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