Homo-PROTAC™ for self-degradation of pVHL30
CM 11 is a PROTAC® for self-degradation of the long form of VHL, pVHL30 (DC50 < 100 nM). Composed of two VHL ligands joined by a linker. Exhibits > 1000-fold increased cellular activity compared to the parent VHL ligand, VH 032. Dimerizes pVHL30 with high avidity
in vitro
. Induced potent and rapid self-degradation of VHL in cell lines in a highly isoform dependent fashion. Negative control CMP 98 (Cat. No. 6417) also available.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124859 |
| Réf. fabricant | 18781839 |
| CAS | 2244684-49-7 |
| Synonyme | N1,N20-bis((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>58</sub>H<sub>82</sub>N<sub>8</sub>O<sub>14</sub>S<sub>2</sub> |
| Poids de la formule | 1179.46 |
| Pureté | 98% |
