Selective PFKFB3 inhibitor
PFK 15 is an originally reported to be a selective PFKFB3 inhibitor (IC50 = 207 nM); a more recent report failed to demonstrate activity in a PFKFB3 kinase assay. Selective for PFKFB3 over a panel of 96 kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits metastasis of Lewis lung carcinoma cell xenografts in mice.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124862 |
| Réf. fabricant | 18788219 |
| Nom chimique ou matériau | PFK 15 |
| CAS | 4382-63-2 |
| Synonyme | 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one |
| Quantité | 10 mg |
| Solubilité | Soluble to 100mM in DMSO |
| Formule moléculaire | C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>2</sub>N<sub>2</sub>O |
| Poids de la formule | 260.29 |
| Forme physique | Solid |
| Type de produit | Bioactive Small Molecule |
| Pureté | >99% |
