KCa1.1 (BK) channel activator
NS 19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips
ex vivo
. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124872 |
| Réf. fabricant | 18710488 |
| Nom chimique ou matériau | 5-[(4-Bromophenyl)methyl]-2-thiazolamine |
| CAS | 327062-46-4 |
| Quantité | 10 mg |
| Cible | Ca2+-Activated Potassium Channel Activators |
| Formule moléculaire | C<sub>10</sub>H<sub>9</sub>BrN<sub>2</sub>S |
| Poids de la formule | 269.16 |
| Pureté | >99% |
