JAK3 kinase inhibitor. Also inhibits EGFR
WHI-P 154 is a JAK3 inhibitor (IC50 = 1.8 μM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages
in vitro
. Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 μM). Induces differentiation of neural progenitor cells.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124893 |
| Réf. fabricant | 18735406 |
| Nom chimique ou matériau | 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol |
| CAS | 211555-04-3 |
| Plage de pourcentage du dosage | >99% |
| Quantité | 25 mg |
| Formule moléculaire | C<sub>16</sub>H<sub>14</sub>BrN<sub>3</sub>O<sub>3</sub> |
| Poids de la formule | Observed MW: 376.2 |
