Selective group III mGlu positive allosteric modulator
VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-124927 |
| Réf. fabricant | 18756499 |
| Nom chimique ou matériau | VU 0422288 |
| CAS | 1630936-95-6 |
| Synonyme | N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide |
| Quantité | 10 mg |
| Solubilité | Soluble to 100mM in DMSO |
| Formule moléculaire | C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>1</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>2</sub> |
| Poids de la formule | 360.19 |
| Forme physique | Solid |
| Type de produit | Bioactive Small Molecule |
| Pureté | >98% |
