Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive
A 317491 sodium salt is a selective, high affinity non-nucleotide P2X3 and P2X2/3 receptor antagonist (Ki values are 9, 22, 22 and 92 nM at human P2X2/3, rat P2X3, human P2X3 and rat P2X2/3, respectively); blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22 - 92 nM). Exhibits selectivity over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes (IC50 > 5 μM). Reduces mechanical allodynia and thermal hyperalgesia in the CCI
in vivo
models. Antinociceptive.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-124950 |
| Réf. fabricant | 18786516 |
| Nom chimique ou matériau | 5-[[[(3-Phenoxyphenyl)methyl][(1 S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt |
| Quantité | 25 mg |
| Cible | P2X Receptor Antagonists |
| Formule moléculaire | C<sub>33</sub>H<sub>25</sub>NO<sub>8</sub>Na<sub>2</sub> |
| Poids de la formule | 609.54 |
| Type de produit | Antagonist |
| Pureté | 98% |
