Selective and potent inhibitor of both mouse and human THIK-1
C 101248 is a selective and potent inhibitor of both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50 = 50 nM); it exhibits no activity against K2P family members, TREK-1 and TWIK-2, and Kv2.1. C 101248 blocks both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of mouse hippocampal microglia. C 101248 reduces neuroinflammation by preventing NLRP3-dependent release of IL-1β in isolated microglia.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125000 |
| Réf. fabricant | 18765715 |
| Nom chimique ou matériau | 4-[1-(4-Pyridinylmethyl)-1 H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine |
| CAS | 361368-24-3 |
| Quantité | 50 mg |
| Cible | Two-P Potassium Channels Blockers |
| Formule moléculaire | C<sub>15</sub>H<sub>12</sub>N<sub>6</sub>O |
| Pureté | 0.98 |
