Enhancer of 20S proteasome assembly and 20S-mediated protein degradation
TCH-165 is an enhancer of 20S proteasome assembly. TCH-165 regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation. TCH-165 enhances the proteolytic activity of the 20S proteasome by increasing substrate accessibility to the 20S catalytic chamber through 20S gate opening. TCH-165 enhances 20S-mediated degradation of IDPs, α-syn, and tau
in vitro
, and does not induce the degradation of structured proteins such as GAPDH. TCH-165 enhances c-MYC degradation by the 20S proteasome, which reduces c-MYC levels
in vivo
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125128 |
| Réf. fabricant | 18765466 |
| Nom chimique ou matériau | Ethyl (4 R,5 R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1 H-imidazole-4-carboxylate |
| CAS | 1446350-60-2 |
| Quantité | 10 mg |
| Cible | Proteasome Modulators |
| Formule moléculaire | C<sub>39</sub>H<sub>37</sub>N<sub>3</sub>O<sub>3</sub> |
| Pureté | 0.98 |
