BIRB 796 is a high affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). Cell permeable.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-125178 |
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| Réf. fabricant | 18757996 |
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| Nom chimique ou matériau | N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea |
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| CAS | 285983-48-4 |
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| Synonyme | Doramapimod |
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| Quantité | 10 mg |
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| Cible | p38 Inhibitors |
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| Formule moléculaire | C<sub>31</sub>H<sub>37</sub>N<sub>5</sub>O<sub>3</sub> |
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| Poids de la formule | 527.66 |
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| Pureté | 0.98 |
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