Ras signaling inhibitor; inhibits Ack1 and GCK
GNF 7 is a potent Bcr-Abl inhibitor (IC50 values are 61 and 133 nM for T315I and wild-type Bcr-Abl, respectively), inhibiting a range of clinically relevant Bcr-Abl mutants such as T315I, G250E, E255V, F317L and M351T. GNF 7 is also a Ras signaling inhibitor as well as inhibiting Ack1 and germinal center kinase (GCK). GNF 7 induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations, and shows growth inhibitory activity in human colon cancer cells. It prolongs survival in a leukemia cell xenotransplantation model in mice and is orally bioavailable.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125225 |
| Réf. fabricant | 18743979 |
| Nom chimique ou matériau | Ras GTPase Inhibitors |
| CAS | 839706-07-9 |
| Quantité | 10 mg |
| Cible | Small G Protein Inhibitors |
| Formule moléculaire | C<sub>28</sub>H<sub>24</sub>F<sub>3</sub>N<sub>7</sub>O<sub>2</sub> |
| Poids de la formule | 547.53 |
| Pureté | >98% |
