ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an
in vitro
model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-125267 |
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| Réf. fabricant | 18718176 |
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| Nom chimique ou matériau | rel-1-[1-[2-[(3 aR,6 AS)-Hexahydrocyclopenta[c]pyrrol-2(1 H)-yl]-2-oxoethyl]-4-piperidinyl]-2,3-dihydro-N-methyl-2-oxo-1 H-indole-5-carboxamide |
|---|
| CAS | 1037834-43-7 |
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| Quantité | 10 mg |
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| Cible | Other Transferase Inhibitors |
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| Formule moléculaire | C<sub>24</sub>H<sub>32</sub>N<sub>4</sub>O<sub>3</sub> |
|---|
| Pureté | 0.98 |
|---|
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