Potent and selective DHODH inhibitor.
Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ∽20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines (ED50 = ∽ 1 μM. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells
in vivo
. Antimetabolite.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125278 |
| Réf. fabricant | 18766016 |
| Nom chimique ou matériau | 6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium |
| CAS | 96201-88-6 |
| Plage de pourcentage du dosage | >99% |
| Quantité | 50 mg |
| Cible | DHODH Inhibitors |
| Formule moléculaire | C<sub>23</sub>H<sub>14</sub>F<sub>2</sub>NO<sub>2</sub>Na |
| Poids de la formule | Observed MW: 397.35 |
