Lomitapide mesylate is a potent inhibitor of microsomal triglyceride transfer protein (IC50 = 8 nM). Lomitapide inhibits or normalizes lipoprotein production in rodents and in a rabbit model of hypercholesterolemia. Lomitapide is antimalarial; it inhibits hemozoin formation and growth of CQ-sensitive (PfNF54) and multidrug-resistant (PfK1) strains of P. falciparum (IC50 values are 0.56 μM and 0.69 μM respectively). Orally bioavailable.
- Nom chimique ou matériau
- N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4 '-(trifluoromethyl)[1,1 '-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9 H-fluorene-9-carboxamide methanesulfonate
- CAS
- 2059395-52-5
- Quantité
- 50 mg
- Cible
- Lipid Metabolism Inhibitors
- Formule moléculaire
- C39H37F6N3O2.CH3SO3H
- Pureté
- 0.98
