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Tocris Bioscience™ SNIPER(ER)-87

Name: Tocris Bioscience™ SNIPER(ER)-87
Brand: Tocris Bioscience
SKU: 18719316
Price: 450.31 EUR
Availability: InStock

Réf. : BL-RE-125326Réf. fabricant : 18719316 5 mg

450,31 € HT

Potent and selective ERα Degrader (SNIPER)

Nom chimique ou matériau: (2 S)-N-[(1 S)-1-Cyclohexyl-2-[(2 S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
CAS: 2222354-91-6
Quantité: 5 mg
Cible: Active Degraders
Formule moléculaire: C₅₉H₇₃N₅O₁₀S
Marque: Tocris Bioscience

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat .No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells

in vitro

and in mouse ovaries

in vivo

Caractéristiques techniques

Marque	Tocris Bioscience
Réf. B-LABO	BL-RE-125326
Réf. fabricant	18719316
Nom chimique ou matériau	(2 S)-N-[(1 S)-1-Cyclohexyl-2-[(2 S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
CAS	2222354-91-6
Quantité	5 mg
Cible	Active Degraders
Formule moléculaire	C<sub>59</sub>H<sub>73</sub>N<sub>5</sub>O<sub>10</sub>S
Pureté	0.98

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Tocris Bioscience™ SNIPER(ER)-87

Caractéristiques techniques

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