Functionalized VHL ligand for PROTACs
VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032; commonly used as a precursor to a PROTAC® that hijacks VHL as the E3 ubiquitin ligase component. Supplied with a primary amine functional handle at a position known not to significantly affect binding to VHL, for ready conjugation to a linker/target protein ligand.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
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| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125350 |
| Réf. fabricant | 18724759 |
| Nom chimique ou matériau | (4 R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride |
| CAS | 2137142-47-1 |
| Synonyme | (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide hydrochloride |
| Quantité | 100 mg |
| Cible | Degrader Building Blocks |
| Formule moléculaire | C<sub>22</sub>H<sub>30</sub>N<sub>4</sub>O<sub>3</sub>S0.2 HCl |
| Poids de la formule | 467.02 |
| Pureté | 98% |
