INT 131 is a potent and selective PPARγ partial agonist (EC50 = 4 nM; Ki = 3.7 nM). It has a 20-fold higher affinity for PPARγ compared with that of Rosiglitazone (Cat. No. 5325). INT 131 improves glucose tolerance in a rodent model of diabetes without inducing hemodynamic and cardiovascular effects. Antidiabetic agent.
- Nom chimique ou matériau
- 2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide
- CAS
- 315224-26-1
- Quantité
- 50 mg
- Cible
- PPAR gamma/NR1C3
- Formule moléculaire
- C21H12Cl4N2O3S
- Pureté
- 0.98
