Potent inhibitor of salt-inducible kinases
ARN 3236 is a potent of salt-inducible kinase 2 (SIK2) inhibitor (IC50 values are <1 nM, 6.63 nM and 21.63 nM for SIK2, SIK3 and SIK1 respectively). ARN 3236 inhibits centrosome separation by uncoupling the centrosome from the nucleus. It also induces cell-cycle arrest and apoptosis by attenuating the AKT/survivin pathway. ARN 3236 inhibits growth and enhances Taxol (Cat. No. 1097) sensitivity in ovarian cancer cell lines
in vitro
and
in vivo
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125382 |
| Réf. fabricant | 18746185 |
| Nom chimique ou matériau | 3-(2,4-Dimethoxyphenyl)-4-(3-thienyl)-1 H-pyrrolo[2,3-b]pyridine |
| CAS | 1613710-01-2 |
| Quantité | 10 mg |
| Cible | SNF1LK2/SIK2 |
| Formule moléculaire | C<sub>19</sub>H<sub>16</sub>N<sub>2</sub>O<sub>2</sub>S |
| Pureté | 0.98 |
