Potent TGF-β receptor type 1 (TGF-βRI) inhibitor
SM 16 is a potent TGF-β receptor type 1 (TGF-βRI) inhibitor (IC50 = 64 nM in luciferase assay). Selective for TGF-βRI over other ALK family members. Decreases Smad phosphorylation and inhibits tumor growth in a mouse xenograft model. Attenuates increased TGF-β signaling in retinal vessels of diabetic rats. Also prevents intimal thickening and vascular remodeling in rat carotid balloon injury model. Orally bioavailable.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125413 |
| Réf. fabricant | 18745576 |
| Nom chimique ou matériau | 4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide |
| CAS | 614749-78-9 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>25</sub>H<sub>26</sub>N<sub>4</sub>O<sub>3</sub> |
| Poids de la formule | 430.5 |
| Type de produit | Inhibitor |
| Pureté | 98% |
