Lopinavir is a highly potent and selective HIV-1 protease inhibitor (IC50 = 6.5 nM, HIV cultured in peripheral blood mononuclear cells; Ki = 1.3 pM). Displays >105-fold selectivity for HIV-1 protease over mammalian proteases including renin and cathepsin D and E. Inhibits HIV-1 protease in patient HIV isolates displaying mutations that confer resistance to ritonavir (Cat. No. 5856) (IC50 values in 5 - 50 nM range). Also inhibits SARS-CoV-2 replication
in vitro
(IC50 = 26 μM)
Caractéristiques techniques
| Marque | Tocris |
|---|
| Réf. B-LABO | BL-RE-125433 |
|---|
| Réf. fabricant | 18775986 |
|---|
| Nom chimique ou matériau | (αS)-N-[(1 S,3 S,4 S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2 H)-pyrimidineacetamide |
|---|
| CAS | 192725-17-0 |
|---|
| Quantité | 50 mg |
|---|
| Cible | Additional Synthetic Protease Inhibitors |
|---|
| Formule moléculaire | C<sub>37</sub>H<sub>48</sub>N<sub>4</sub>O<sub>5</sub> |
|---|
| Pureté | 0.98 |
|---|
Une question, une configuration particulière ?
Contactez-nous pour un devis.
