PF 06551600 malonate is a potent and selective JAK3 inhibitor (IC50 = 33.1 μM). Exhibits no significant activity against a panel of other kinases including JAK1, JAK2 and TYK2. Inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. Suppresses Th1 and Th17 T-cell differentiation and function
in vitro
. Reduces paw swelling in a rat model of arthritis and reduces disease severity in a rat EAE model.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-125458 |
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| Réf. fabricant | 18749568 |
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| Nom chimique ou matériau | 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate |
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| CAS | 2140301-97-7 |
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| Quantité | 5 mg |
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| Formule moléculaire | C<sub>15</sub>H<sub>19</sub>N<sub>5</sub>O.C<sub>3</sub>H<sub>4</sub>O<sub>4</sub> |
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| Pureté | 98% |
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