LM22B 10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.
- Nom chimique ou matériau
- 2,2′,2′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol
- CAS
- 342777-54-2
- Quantité
- 50 mg
- Formule moléculaire
- C27H33ClN2O4
- Pureté
- 98%
