VU 0071063 is a selective activator of SUR1 Kir6.2 channels and pancreatic β-cell KATP channels (EC50 = 7 μM and 0.3-10.3 μM, respectively). VU 0071063 inhibits insulin secretion in pancreatic β-cells by inducing hyperpolarization of β-cell membranes and reduces voltage-dependent calcium channel activation and Ca2+ influx. VU 0071063 is active in vivo and brain penetrant.
- Nom chimique ou matériau
- 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1 H-purine-2,6-dione
- CAS
- 333415-38-6
- Quantité
- 50 mg
- Cible
- Inward Rectifier Potassium Channel Activators
- Formule moléculaire
- C18H22N4O2
- Pureté
- 0.98
