"/> Tocris Bioscience™ LEI 401 | B-LABO France

Tocris Bioscience™ LEI 401

Réf. : BL-RE-125602Réf. fabricant : 18795906 10 mg
281,85 € HT

High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor

Nom chimique ou matériau
N-(Cyclopropylmethyl)-6-[(3 S)-3-hydroxy-1-pyrrolidinyl]-2-[(3 S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide
CAS
2393840-15-6
Quantité
10 mg
Cible
Phospholipase Inhibitors
Formule moléculaire
C24H31N5O2
Marque
Tocris Bioscience

LEI 401 is a high affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor (Ki = 0.027 and 0.18 μM for human and mouse NAPE-PLD, respectively; IC50 for human enzyme = 0.86 μM). LEI 401 exhibits no significant activity at cannabinoid receptors or other metabolic enzymes of the endocannabinoid system. The product reduces levels of N-acylethanolamines (NAE) in a neuroblastoma cell line

in vitro

. It also reduces anandamide levels in mouse brain

in vivo

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-125602
Réf. fabricant18795906
Nom chimique ou matériauN-(Cyclopropylmethyl)-6-[(3 S)-3-hydroxy-1-pyrrolidinyl]-2-[(3 S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide
CAS2393840-15-6
Quantité10 mg
CiblePhospholipase Inhibitors
Formule moléculaireC<sub>24</sub>H<sub>31</sub>N<sub>5</sub>O<sub>2</sub>
Pureté0.98
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