"/> Tocris Bioscience™ VU 0467485 | B-LABO France

Tocris Bioscience™ VU 0467485

Réf. : BL-RE-125606Réf. fabricant : 18708466 50 mg
1 074,49 € HT

Potent and selective positive allosteric modulator of M4 receptors; orally bioavailable and brain penetrant

Nom chimique ou matériau
5-Amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
CAS
1451994-10-7
Quantité
50 mg
Formule moléculaire
C17H17FN4O2S
Pureté
98%
Marque
Tocris Bioscience

VU 0467485 is a potent and selective positive allosteric modulator of M4 receptor; potentiates activity of ACh at M4 (EC50 values are 26.6 and 78.8 nM at rat and human M4 receptors, respectively). Exhibits selectivity for M4 over human and rat M1-3, 5, and a panel of 200 other pharmacological targets. Displays efficacy in a rat model of antipsychotic activity. Orally bioavailable and brain penetrant.

Caractéristiques techniques

MarqueTocris Bioscience
Réf. B-LABOBL-RE-125606
Réf. fabricant18708466
Nom chimique ou matériau5-Amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
CAS1451994-10-7
Quantité50 mg
Formule moléculaireC<sub>17</sub>H<sub>17</sub>FN<sub>4</sub>O<sub>2</sub>S
Pureté98%
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