NS 8593 hydrochloride is a selective KCa2 (SK) channel negative modulator; inhibits SK channel currents (Kd values are 0.42, 0.6 and 0.73 μM for SK1, SK2 and SK3 respectively at 0.5 μM Ca2+). Exhibits selectivity for SK channels over KCa1.1 (BK), KCa3.1 (IK), Kv, Nav and Cav channels. Inhibits afterhyperpolarization in hippocampal slices.
- Nom chimique ou matériau
- NS 8593 hydrochloride
- CAS
- 875755-24-1
- Synonyme
- N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride
- Quantité
- 50 mg
- Solubilité
- Soluble to 100mM in DMSO and to 20mM in ethanol
- Formule moléculaire
- C17H17N3·HCl
- Poids de la formule
- 299.8
- Forme physique
- Solid
- Type de produit
- Bioactive Small Molecule
- Pureté
- >98%
