Liquid-liquid phase separated condensate modifier; reduces stress granule formation
(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in
D. melanogaster
expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs
in vitro
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125705 |
| Réf. fabricant | 18749406 |
| Nom chimique ou matériau | 1,2-Dithiolane-3-pentanoic acid |
| CAS | 1077-28-7 |
| Quantité | 100 mg |
| Formule moléculaire | C<sub>8</sub>H<sub>14</sub>O<sub>2</sub>S<sub>2</sub> |
| Pureté | 98% |
