Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment
StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells
ex vivo
. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125717 |
| Réf. fabricant | 18786766 |
| Nom chimique ou matériau | 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9 H-purin-6-yl]amino]ethyl]phenol |
| CAS | 1227633-49-9 |
| Quantité | 10 mg |
| Cible | Aryl Hydrocarbon Receptor Antagonists |
| Formule moléculaire | C<sub>24</sub>H<sub>23</sub>N<sub>5</sub>OS |
| Pureté | 0.98 |
