Inhibitor of mitotic motor kinesin Eg5
Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Arrests mitosis, triggers apoptosis and up-regulates Hsp-70 expression in multiple human myeloma cell lines. Also inhibits the growth of several types of cancer cell lines (EC50 values are 330, 603, 743 and 881 nM in HCT116, Htert-HME1, BxPC3, K562 and NCI-H1299 cancer cells, respectively). Suppresses the migration and invasion of PANC1 cells
in vitro
. Cytoprotective.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125733 |
| Réf. fabricant | 18750268 |
| Nom chimique ou matériau | 2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone |
| CAS | 863774-58-7 |
| Quantité | 50 mg |
| Cible | Kinesin Inhibitors |
| Formule moléculaire | C<sub>16</sub>H<sub>18</sub>N<sub>2</sub>O<sub>2</sub>S |
| Poids de la formule | 302.39 |
| Pureté | >99% |
