TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC50 values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC50 = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.
- Nom chimique ou matériau
- N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5 H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2 H-pyran-4-aminium chloride
- CAS
- 229005-80-5
- Quantité
- 50 mg
- Cible
- Chemokine Receptor Antagonists
- Formule moléculaire
- C33H39N2O2.Cl
- Pureté
- 0.98
