PZM21 is a selective μ receptor agonist (EC50 = 4.6 nM). PZM21 has been reported to exhibit bias for the Gi signaling pathway over arrestin-3. The compound exhibits 500-fold selectivity for μ over δ receptors and no detectable activity at κ or nociceptin receptors and a panel of 316 other GPCRs. PZM21 induces analgesia in a mouse hot plate assay, but not a tail-flick assay and exhibits no significant conditioned place preference response in in vivo assays. CNS penetrant.
- Nom chimique ou matériau
- N-[(2 S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1 S)-1-methyl-2-(3-thienyl)ethyl]urea
- CAS
- 1997387-43-5
- Cible
- mu Opioid Receptor Agonists
- Formule moléculaire
- C19H27N3O2S
- Pureté
- 0.98
