SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC50 = 2.1 nM). The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines. (EC50 values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively).
In vivo
, SJ 6986 is stable in mouse (t1/2 = 4.7 h). This product is orally bioavailable.
Caractéristiques techniques
| Marque | Tocris Bioscience |
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| Réf. B-LABO | BL-RE-125787 |
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| Réf. fabricant | 18726526 |
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| Nom chimique ou matériau | N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide |
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| CAS | 2765625-93-0 |
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| Quantité | 10 mg |
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| Cible | Molecular Glues |
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| Formule moléculaire | C<sub>20</sub>H<sub>14</sub>F<sub>3</sub>N<sub>3</sub>O<sub>7</sub>S |
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| Pureté | 0.98 |
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