Competitive PTP1B inhibitor
CX08005 is a competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR) . Enhances insulin-induced glucose uptake in adipocytes and myotubes
in vitro
. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125800 |
| Réf. fabricant | 18746179 |
| Nom chimique ou matériau | 2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid |
| CAS | 1256341-22-6 |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>28</sub>H<sub>39</sub>N0<sub>4</sub> |
| Pureté | 98% |
