"/> Tocris™ FMF-04-159-2 | B-LABO France

Tocris™ FMF-04-159-2

Réf. : BL-RE-125807Réf. fabricant : 18797136 10 mg
345,56 € HT

Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

Nom chimique ou matériau
N-[1-[[3-[[(2 E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6- trichlorobenzoyl)amino]-1 H-pyrazole-3-carboxamide
CAS
2364489-81-4
Quantité
10 mg
Cible
Cyclin-dependent Kinase Inhibitors
Formule moléculaire
C28H30Cl3N7O5S
Marque
Tocris

FMF-04-159-2 is a potent inhibitor of CDK14 and CDK16 (IC50 = 40 nM for CDK14 in cellular BRET assay; IC50 values are 88 and 10 nM for CDK14 and CDK16 in kinase activity inhibition assay, respectively). Inhibits other TAIRE kinase family members at 1 μM (CDK17 and CDK18). Also binds CDK2 (IC50 = 256 nM). Displays covalent binding of CDK14, with binding sustained after washout. Causes cell cycle arrest at G2/M in cancer cell lines. Reversible control FMF-04-159-R (Cat. No. 7159) also available.

Caractéristiques techniques

MarqueTocris
Réf. B-LABOBL-RE-125807
Réf. fabricant18797136
Nom chimique ou matériauN-[1-[[3-[[(2 E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6- trichlorobenzoyl)amino]-1 H-pyrazole-3-carboxamide
CAS2364489-81-4
Quantité10 mg
CibleCyclin-dependent Kinase Inhibitors
Formule moléculaireC<sub>28</sub>H<sub>30</sub>Cl<sub>3</sub>N<sub>7</sub>O<sub>5</sub>S
Pureté0.98
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