Potent pan-AKT inhibitor
AZD 5363 is a potent pan-AKT inhibitor (IC50 values are 3, 7 and 7 nM for AKt 1, 2 and 3, respectively). Also inhibits P70S6K, PKA, ROCK2 and ROCK1 (IC50 values are 6, 7, 60 and 470 nM, respectively). Inhibits growth of tumor cell lines
in vitro
, particularly breast, endometrial, gastric, hematologic and prostate cancers. Inhibits growth of human tumor xenografts in mice. Enhances
in vivo
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125848 |
| Réf. fabricant | 18034782 |
| Synonyme | Capivasertib |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>21</sub>H<sub>25</sub>ClN<sub>6</sub>O<sub>2</sub> |
| Poids de la formule | 428.92 |
| Type de produit | Inhibitor |
| Pureté | 98% |
