Positive allosteric modulator of KCa3.1 (IK) channels
SKA 121 is a positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50 = 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KV and NaV channels. Potentiates bradykinin-induced vasodilation
ex vivo
. Lowers mean arterial blood pressure in normotensive and hypertensive mice.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125898 |
| Réf. fabricant | 18755646 |
| Nom chimique ou matériau | 5-Methylnaphth[2,1-d]oxazol-2-amine |
| CAS | 1820708-73-3 |
| Quantité | 5 mg |
| Cible | Ca2+-Activated Potassium Channel Activators |
| Formule moléculaire | C<sub>12</sub>H<sub>10</sub>N<sub>2</sub>O |
| Poids de la formule | 960 |
| Pureté | 98% |
