High affinity PARP-1 and -2 inhibitor; orally bioavailable
Veliparib dihydrochloride is a high affinity PARP-2 and PARP-1 inhibitor (Ki values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125903 |
| Réf. fabricant | 18717816 |
| Nom chimique ou matériau | 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride |
| CAS | 912445-05-7 |
| Quantité | 50 mg |
| Formule moléculaire | C<sub>13</sub>H<sub>16</sub>N<sub>4</sub>O.2HCl |
| Pureté | 98% |
