Selective dual melatonin receptor (MT1/MT2) agonist
Tasimelteon is a high affinity and selective dual melatonin receptor (MT1/MT2) agonist (Ki values are 0.304 nM and 0.0692 nM, respectively). It has no significant interaction with any other commonly screened receptors or enzyme binding sites. Tasimelteon induces a potent, concentration-dependent inhibition of forskolin-stimulated cAMP accumulation in NIH-3T3 cells stably expressing human MT1 (EC50 = 0.74 nM) or expressing human MT2 (EC50 = 0.1 nM) receptors. Tasimelteon is a circadian regulator.
| Marque | Tocris Bioscience |
|---|---|
| Réf. B-LABO | BL-RE-125909 |
| Réf. fabricant | 18709116 |
| Nom chimique ou matériau | N-[[(1 R,2 R)-2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide |
| CAS | 609799-22-6 |
| Quantité | 50 mg |
| Cible | Melatonin (MT) Receptor Agonists |
| Formule moléculaire | C<sub>15</sub>H<sub>19</sub>NO<sub>2</sub> |
| Pureté | 0.98 |
