Selective high affinity human sst4 agonist
J 2156 is a high affinity human somatostatin receptor 4 (sst4) agonist (Ki = 1.2 nM). Displays >400-fold selectivity for human sst4 over other human sst receptor subtypes. Exhibits 2 to 3-fold more potent agonism
in vitro
than endogenous ligands somatostatin-14 (Cat. No. 1157) and somatostatin-28 (Cat. No. 1165). Reduces inflammatory airway hyperresponsiveness in acute and chronic airway inflammation models in mice. Exhibits anxiolytic effects in elevated plus maze test in mice.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125929 |
| Réf. fabricant | 18746036 |
| Nom chimique ou matériau | (1'S,2S)-4-Amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4"-methyl-1"-naphthalenesulfonylamino)butanamide trifluoroacetate |
| CAS | 2387505-73-7 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>24</sub>H<sub>28</sub>N<sub>4</sub>O<sub>4</sub>S.C<sub>2</sub>HF<sub>3</sub>O<sub>2</sub> |
| Pureté | 98% |
