Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1)
KYT 0353 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1) (IC50 = 60 nM for 14C-leucine uptake in H-29 cells). Also suppreses 14C-leucine uptake in renal proximal tubule cells expressing LAT1 (IC50 = 140 nM). Displays ∽500-fold selectivity for LAT1 over LAT2. Reduces cell viability and induces apoptosis in YD-38 oral cancer cells. Arrests growth in several tumor cell lines. Exhibits growth inhibitory effects on HT-29 cells
in vivo
.
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125953 |
| Réf. fabricant | 18769216 |
| Nom chimique ou matériau | <i>O</i>-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride |
| CAS | 1597402-27-1 |
| Synonyme | JPH 203 |
| Quantité | 5 mg |
| Formule moléculaire | C<sub>23</sub>H<sub>19</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>4</sub>.2HCl |
| Poids de la formule | 545.24 |
| Type de produit | Inhibitor |
| Pureté | 96% |
