EN6 is an activator of lysosomal vacuolar H+ ATPase (v-ATPase). EN6 covalently binds to the catalytic subunit of v-ATPase leading to increased acidification of lysosomes, inactivation of mTORC1 signaling and activation of autophagy in vivo. EN6 triggers entosis and promotes clearance of TDP43 protein aggregates in vitro.
- Nom chimique ou matériau
- N-[4-Fluoro-3-[(1-oxo-2-propen-1-yl)amino]phenyl]-1-(2-fluorophenyl)-1 H-pyrazole-4-carboxamide
- CAS
- 1808714-73-9
- Quantité
- 10 mg
- Cible
- H+-ATPase Inhibitors
- Formule moléculaire
- C19H14F2N4O2
- Pureté
- 0.98
