Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF-α stimulated lung epithelial cells
in vitro
. Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs
in vivo
| Marque | Tocris |
|---|---|
| Réf. B-LABO | BL-RE-125964 |
| Réf. fabricant | 18756896 |
| Quantité | 10 mg |
| Formule moléculaire | C<sub>19</sub>H<sub>18</sub>BrIN<sub>4</sub>O<sub>2</sub> |
| Poids de la formule | 541.18 |
| Type de produit | Inhibitor |
| Pureté | 98% |
